Late changes in peripheral blood and spleen in mice after the effect of single whole body irradiation with the dose of 8 Gy.

Abstract

Late haematopoietic changes were followed within 12-16 months after single whole body irradiation with the dose of 8 Gy. Permanently increased frequency of occurrence of cytopathologically altered leukocytes was observed in peripheral blood in irradiated animals as well as certain disorder of erythropoietic system. At the end of period followed the splenomegalia accompanied with marked macroscopic and microscopic changes was occurred. With simultaneous increase of occurrence of erythroblasts in peripheral blood the changes above are considered to be a symptom of erythroleukaemia.