L.B. Heifets, Pamela J. Lindholm-Levy, Marcella Flory
{"title":"Thiacetazone: in vitro activity against mycobacterium avium and m. tuberculosis","authors":"L.B. Heifets, Pamela J. Lindholm-Levy, Marcella Flory","doi":"10.1016/0041-3879(90)90043-8","DOIUrl":null,"url":null,"abstract":"<div><p>Bacteriostatic and bactericidal activity of thiacetazone was determined for 68 <em>M. avium</em> clinical isolates and 14 wild drug-susceptible <em>M. tuberculosis</em> strains. The drug had equally low bactericidal activity against both mycobacterial species. The inhibitory activity against most of the <em>M. avium</em> strains was greater than it was against <em>M. tuberculosis</em>. The broth determined MICs for 65 of 68 <em>M. avium</em> strains were between 0.02 and 0.15 μg/ml, while the MICs for <em>M. tuberculosis</em> ranged from 0.08 to 1.2 μg/ml.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 4","pages":"Pages 287-291"},"PeriodicalIF":0.0000,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90043-8","citationCount":"20","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tubercle","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0041387990900438","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 20
Abstract
Bacteriostatic and bactericidal activity of thiacetazone was determined for 68 M. avium clinical isolates and 14 wild drug-susceptible M. tuberculosis strains. The drug had equally low bactericidal activity against both mycobacterial species. The inhibitory activity against most of the M. avium strains was greater than it was against M. tuberculosis. The broth determined MICs for 65 of 68 M. avium strains were between 0.02 and 0.15 μg/ml, while the MICs for M. tuberculosis ranged from 0.08 to 1.2 μg/ml.
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