Correlación entre testosterona total y resultado histopatológico en pacientes sometidos a prostatectomía radical retropúbica

Abstract

Background

The role of hormonal influence on prostate cancer is reflected mainly on the effect of androgen deprivation therapy in metastatic disease. Nevertheless, in localized prostate cancer there is increasing evidence of a more aggressive clinical course directly correlated with low serum total testosterone levels.

Aim

To analyze the correlation between preoperative serum total testosterone levels and the histologic grade obtained through transrectal biopsy and the definitive anatomopathologic report in patients that underwent open radical retropubic prostatectomy at a tertiary care hospital in Mexico City.

Methodology

A retrospective, observational, analytic study was conducted that included 52 patients operated on with open radical retropubic prostatectomy at a tertiary care hospital in Mexico City. A correlation was established between low serum total testosterone levels and the Gleason score obtained through transrectal biopsy and the definitive histopathologic report, as well as surgical margin status.

Results

A statistically significant association was found between low serum total testosterone levels and a Gleason score of 8 or higher in the definitive histopathologic report after radical prostatectomy (P = .00165), positive surgical margins (P = .0148), and the presence of locally advanced disease after the analysis with the Fisher's exact test (P = .0110).

Conclusions

The present study showed positive results in relation to the influence of total testosterone on the histopathologic variables that determine cancer-specific survival in localized prostate cancer, consistent with numerous case series reported in the literature.