In vivo lipid and amino acid synthesis from 3-hydroxybutyrate in 15-day-old chick.

G J Caamaño, M A Sanchez-Del-Castiool, A Linares, E Garcia-Peregrin
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引用次数: 5

Abstract

The in vivo utilization of 3-hydroxybutyrate for lipid and amino acid synthesis in liver, kidney and duodenal mucosa of overnight-starved 15-day-old chicks has been investigated. Lipid synthesis was higher in liver and duodenal mucosa than in kidney. Triglycerides were the main lipids synthesized from 3-hydroxybutyrate in liver and kidney, while in duodenal mucosa a higher amount of phospholipids was observed. This tissue utilized a high percentage of 3-hydroxybutyrate for the synthesis of free cholesterol, in agreement with the major role of intestine in body cholesterogenesis. All of the assayed tissues synthesized amino acids from 3-hydroxybutyrate at a similar rate, glutamate being always the main amino acid formed.

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3-羟基丁酸在15日龄鸡体内脂质和氨基酸的合成。
本试验研究了3-羟基丁酸盐在15日龄夜间饥饿雏鸡肝脏、肾脏和十二指肠黏膜合成脂质和氨基酸中的体内利用情况。肝脏和十二指肠黏膜的脂质合成高于肾脏。肝脏和肾脏中3-羟基丁酸酯合成的脂质以甘油三酯为主,十二指肠黏膜中磷脂含量较高。该组织利用高比例的3-羟基丁酸盐合成游离胆固醇,这与肠道在体内胆固醇生成中的主要作用一致。所有被测组织都以相似的速率从3-羟基丁酸合成氨基酸,谷氨酸始终是主要形成的氨基酸。
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