[Malondialdehyde formation by platelets of hemophiliacs].

Abstract

The platelets of haemophilic patients produce after stimulation with thrombin (5 NIH-units) a significantly reduced amount of malondialdehyde in comparison to the platelets of healthy children of the same age. There is a positive correlation between the platelet count in citrated whole blood and malondialdehyde production in the group of healthy children, however the same correlation is negative in adults and strongly negative in haemophiliacs. Because of the 24 hour-intervals between the last substitution and investigation in the majority of haemophilic patients, the reduced MDA-production of their platelets seems to be the result of side effects of the administration of plasma fractions. On the other hand, the reduced capacity for the MDA-production of the platelets of haemophiliacs can be explained as the result of the release reaction of platelets after haemostasis activation following bleedings.