[Epitope analysis of CD68 antigens].

Allergie und Immunologie Pub Date : 1991-01-01
D Ulsijchutagijn, H Kupper, W Eichler, H Fiebig
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Abstract

Different epitopes of CD68 antigen are detectable by three new generated monoclonal antibodies (MABs) BL-M68/1-3 (all mouse IgM). The MAB BL-M68/3 reacts with an epitope, which is stable also in formalin-fixed paraffin-embedded tissues. In immunohistochemical blocking experiments using the own biotinylated MABs and six CD68 MABs from the IV. Workshop on Human Leucocyte Differentiation Antigens two new epitopes could be defined. The number of known CD68 epitopes increases at least up to seven.

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[CD68抗原表位分析]。
三种新生成的单克隆抗体(MABs) BL-M68/1-3(均为小鼠IgM)可检测不同的CD68抗原表位。MAB BL-M68/3与一个表位反应,该表位在福尔马林固定石蜡包埋组织中也是稳定的。在免疫组织化学阻断实验中,使用自己的生物素化单克隆抗体和来自第四届人类白细胞分化抗原研讨会的6个CD68单克隆抗体,可以定义两个新的表位。已知CD68表位的数量至少增加到7个。
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