Estimulación transcutánea del nervio tibial posterior versus darifenacina para el tratamiento de vejiga hiperactiva refractaria en mujeres

N.N. Macías-Vera, P.I. Velázquez-Castellanos, N. Godoy-Rodríguez
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引用次数: 4

Abstract

Aim

To compare the results of transcutaneous posterior tibial nerve stimulation vs. darifenacin for the treatment of refractory overactive bladder in women.

Material and methods

A quasi-experimental clinical trial was conducted on 30 women diagnosed with refractory overactive bladder. Twenty-two patients received 7.5 mg of oral darifenacin daily and 8 patients had 12 30-min weekly sessions of transcutaneous electrostimulation of the posterior tibial nerve. The patients kept a 3-day urinary diary, underwent pad tests, and the quality of life Bladder Control Self-Assessment Questionnaire and International Consultation on Incontinence Questionnaire were applied at the baseline, at 6 weeks, and at 12 weeks of the study.

Results

At 6 weeks, the patients treated with darifenacin presented with a reduction in urinary frequency (8.27 vs. 11.5, p = 0.236), in nocturia (1.36 vs. 4.25, p = 0.017), and in incontinence episodes (1.32 vs. 3.62, p = 0.041), compared with the patients that received stimulation treatment. In regard to the quality of life questionnaires, at 6 weeks the patients that received darifenacin treatment had a lower score on the self-assessment questionnaire (7.13 vs. 10.14, p = 0.045). In relation to the pad test, after comparing the measurements at the beginning and end of treatment, there was reduced urine leakage in grams with darifenacin (69.32 vs. 2.09, p = 0.041) and with stimulation (42.25 vs. 2.62, p = 0.012), with no statistical significance between the 2 groups (p = 0.753).

Conclusions

Darifenacin was superior to transcutaneous stimulation of the posterior tibial nerve in relation to symptom reduction, urine leakage, and questionnaire scores at 6 weeks. There was no statistically significant difference between the 2 groups at 12 weeks.

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经皮胫骨后神经刺激与达非那新治疗女性难治性膀胱过度活跃
目的比较经皮胫后神经刺激与达利那新治疗难治性膀胱过动症的疗效。材料与方法对30例难治性膀胱过动症患者进行准实验性临床试验。22例患者每日口服达利那新7.5 mg, 8例患者每周进行12次经皮胫后神经电刺激,每次30分钟。患者记录3天尿日记,进行尿垫试验,生活质量膀胱控制自我评估问卷和尿失禁国际咨询问卷分别在研究的基线、6周和12周使用。结果6周时,与刺激组相比,达利那新组患者尿频减少(8.27 vs 11.5, p = 0.236),夜尿减少(1.36 vs 4.25, p = 0.017),尿失禁减少(1.32 vs 3.62, p = 0.041)。在生活质量问卷调查中,在6周时,接受达利那新治疗的患者在自我评估问卷上得分较低(7.13比10.14,p = 0.045)。与尿垫试验相比,在治疗开始和结束时的测量值比较,达利那新组(69.32 vs. 2.09, p = 0.041)和刺激组(42.25 vs. 2.62, p = 0.012)的尿漏克数减少,两组间差异无统计学意义(p = 0.753)。结论达利那新在缓解症状、尿漏和6周问卷评分方面优于经皮刺激胫后神经。12周时两组比较无统计学差异。
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来源期刊
Revista mexicana de urologia
Revista mexicana de urologia Medicine-Urology
CiteScore
0.20
自引率
0.00%
发文量
49
期刊介绍: Revista Mexicana de Urología (RMU) [Mexican Journal of Urology] (ISSN: 0185-4542 / ISSN electronic: 2007-4085) is bimonthly publication that disseminates research by academicians and professionals of the international medical community interested in urological subjects, in the format of original articles, clinical cases, review articles brief communications and letters to the editor. Owing to its nature, it is publication with international scope that disseminates contributions in Spanish and English that are rigorously reviewed by peers under the double blind modality. Neither journalistic documents nor those that lack rigorous medical or scientific support are suitable for publication.
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