Risk Factors for Fracture Events in Maintenance Hemodialysis Patients

Abstract

Objective: To explore risk factors for fracture events in maintenance hemodialysis patients. Methods: The study population was obtained from the hospital in patient database in China. There were 654 eligible patients with hemodialysis from 2018 – 2020. Other patient-related variables collected include gender, age, history of hypertension, history of diabetes mellitus, dialysis age, active vitamin D, hemoglobin, serum albumin, total cholesterol, triglyceride, serum corrected calcium. The primary outcome was any factors of fracture. Patients were followed until complete treatment or death. Besides, we performed subgroup analyses and used generalized linear models to assess interaction effects in logistic regressions. To clarify the relationship between fracture and risk factors, logistic regression was used. Result: By comparing non-fracture group and fracture group, we found that some factors were significantly difference, including gender, age, active vitamin D, and albumin (p = 0.001, p = 0.001, p < 0.001, p < 0.001). base on multivariate Logistic regression analysis of fracture occurrence in hemodialysis patients, older age, female, and low albumin were independent risk factors for fracture (p < 0.05). Also, the use of active vitamin D is a protective factor for fractures (p < 0.05). Conclusion: the risk factors for fracture events in maintenance hemodialysis patients included older age, female, low albumin, and active vitamin D.