Age-related changes in calcitonin gene-related peptide (CGRP)-mediated neurogenic vasodilation of the mesenteric resistance vessel in SHR.

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1991-01-01 DOI:10.3109/10641969109042077

H Kawasaki, A Saito, K Goto, K Takasaki

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引用次数: 10

Abstract

Age-related changes in CGRP-containing vasodilator nerve activity in hypertension were studied in perfused mesenteric vascular beds isolated from SHR and normotensive rats (WKY). Perivascular nerve stimulation (PNS; 0.5-8 Hz) of both SHR and WKY preparations with active tone produced a frequency-dependent vasodilator response, which was abolished by 100 nM tetrodotoxin, 500 nM capsaicin or cold storage denervation. This response in SHR greatly decreased with age, whereas the response in WKY slightly decreased with age. The neurogenic vasodilation in 15- and 30-week-old SHR but not 8-week-old SHR was significantly smaller than that in age-matched WKY. Vasodilator responses to exogenous CGRP (0.1-30 nM) in SHR increased with age, whereas an age-related decrease in the vasodilation was found in WKY. Immunohistochemical studies showed an age-related decrease in CGRP-containing fibers in SHR. These results suggest that CGRP-containing vasodilator innervation is greatly decreased when SHR develop and maintain hypertension.

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SHR中降钙素基因相关肽(CGRP)介导的肠系膜抵抗血管神经源性舒张的年龄相关变化

在SHR和正常血压大鼠(WKY)分离的灌注肠系膜血管床中，研究了高血压患者含cgrp血管舒张神经活性的年龄相关性变化。血管周围神经刺激;0.5-8 Hz)的活性调制剂均产生频率依赖性血管扩张反应，100 nM河豚毒素、500 nM辣椒素或冷藏去神经可消除该反应。随着年龄的增长，SHR的这种反应大大降低，而WKY的这种反应略有下降。15和30周龄SHR的神经源性血管舒张明显小于年龄匹配的WKY，但8周龄SHR无神经源性血管舒张。SHR对外源性CGRP (0.1-30 nM)的血管舒张反应随着年龄的增长而增加，而WKY的血管舒张反应则随着年龄的增长而下降。免疫组织化学研究显示SHR中含cgrp纤维的减少与年龄相关。这些结果表明，当SHR发生并维持高血压时，含cgrp的血管舒张神经支配明显减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical and experimental hypertension. Part A, Theory and practice

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