Application of Metal-Organic Frameworks in Imaging-Guided Therapy

Abstract

Metal-organic frameworks (MOFs) are formed by the self-assembly of metal centres/clusters and organic ligands. A diverse range of organic ligands can be employed, including nucleobases, amino acids, peptides, proteins, and saccharides et al. Due to the characteristics of large surface area, high porosity, easy surface functionalization and adjustable internal pore size, et al. MOFs have been used as a significant emerging class of biological imaging agents and have attracted great research interest in optical imaging (OI), photoacoustic imaging (PAI), magnetic resonance imaging (MRI), computer tomography (CT) and positron emission tomography (PET) in recent years. This review provides a comprehensive overview of the diverse range of organic ligands utilized in Metal-organic frameworks, while also delving into the recent advancements, opportunities, and challenges encountered in the realm of bioimaging in recent years.