Mitoxantrone in malignant pleural mesothelioma: A study by the EORTC lung cancer cooperative group

Frans J.M. van Breukelen , Karin Mattson , Giuseppe Giaccone , Nico van Zandwijk , Hans T. Planteydt , Anne Kirkpatrick , Otilia Dalesio
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引用次数: 46

Abstract

46 patients with malignant pleural mesothelioma were entered in a phase II study of mitoxantrone 14 mg/m2 every 3 weeks. Histology was confirmed by a pathology panel. None of the patients had received previous chemotherapy. Toxicity was mainly mild gastrointestinal and haematological side-effects. Out of 34 patients evaluated for response, only 1 partial response was recorded. Mitoxantrone at this dose and schedule has marginal activity in malignant mesothelioma.

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米托蒽醌治疗恶性胸膜间皮瘤:EORTC肺癌合作组的研究
46例恶性胸膜间皮瘤患者每3周服用米托蒽醌14mg /m2进行II期研究。病理检查证实了组织学。这些患者之前都没有接受过化疗。毒副作用主要是轻微的胃肠道和血液学副作用。在34例评估缓解的患者中,仅记录了1例部分缓解。米托蒽醌在这种剂量和方案下对恶性间皮瘤有边际活性。
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