Multi-abstraction modeling in synthetic biology

Abstract

Synthetic biology is a science resulting from the connection between biotechnology and engineering sciences. It aims to design and build new biological systems and functions. The ability to design a new biological function according to given specifications includes many steps. One of the big issues is to formalize a design methodolgy and to develop adapted tools. One way to explore is to adapt the design flow used in digital microelectronics to synthetic biology. The paper focuses on a key point of the design flow, which is the development of a multi-abstraction model library for BioBricks, which is the basis of a design kit, provided to biodesigners, for simulation purposes. For each abstraction level, we present the way the model is built. The pertinence of each model is presented as well.