Calpain and kininogen mediated inflammation.

Biomedica biochimica acta Pub Date : 1991-01-01
M Sasaki, M Kunimatsu, T Tada, J Nishimura, X J Ma, I Ohkubo
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Abstract

On the basis of previous findings that N-acetyl nonapeptide from the human calpain I large subunit has chemotactic activity for neutrophils, more than 30N-acetyl and unmodified peptides which have N-terminal amino acid sequences of the large and small subunits of calpains I and II were synthesized and their chemotactic activity was estimated. In addition to the above N-acetyl nonapeptide from the calpain I large subunit, an unmodified nonapeptide from the calpain II large subunit and several N-acetyl peptides of different lengths from the small subunit showed chemotactic activity. Furthermore, when calpain was incubated with either high molecular weight or low molecular weight kininogen, kinin liberation occurred with simultaneous inhibition of calpain by kininogen. These data suggest that chemical mediators generated from the calpain-kininogen system may participate in migration and accumulation of neutrophils to the inflammatory locus.

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钙蛋白酶和激肽原介导的炎症。
在前人研究发现人calpain I大亚基n -乙酰基非肽对中性粒细胞具有趋化活性的基础上,合成了30多个具有calpain I和calpain II大亚基和小亚基n端氨基酸序列的n -乙酰基和未修饰肽,并对其趋化活性进行了估计。除了上述来自calpain I大亚基的n -乙酰基非肽外,来自calpain II大亚基的未修饰的非肽和来自calpain II小亚基的不同长度的n -乙酰基肽均表现出趋化活性。此外,当钙蛋白酶与高分子量或低分子量激肽原孵育时,激肽原在抑制钙蛋白酶的同时释放。这些数据表明,由calpain- kinin原系统产生的化学介质可能参与了中性粒细胞向炎症位点的迁移和积累。
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