Rapid accumulation of plasma acid-stable trypsin inhibitor in experimental acute renal injury.

Enzyme Pub Date : 1991-01-01 DOI:10.1159/000468865
M Maruyama, E Yoshida, M Sugiki, H Mihara, H Sumi, R Sakai
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引用次数: 1

Abstract

Acid-stable trypsin inhibitor (ASTI) activity was measured during experimental acute renal tubular dysfunction and glomerulonephritis in rats. A marked elevation of ASTI activity occurred at a very early stage of acute renal tubular damage, and the changes were observed prior to histological abnormalities or elevation of blood creatinine. No alteration in ASTI activity was observed at an early stage of experimental glomerulonephritis. The data obtained confirm that ASTI is excreted through the renal tubules and that the plasma ASTI concentration is very sensitive to renal tubular dysfunction.

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血浆酸稳定型胰蛋白酶抑制剂在实验性急性肾损伤中的快速积累。
测定了大鼠急性肾小管功能障碍和肾小球肾炎时胃酸稳定型胰蛋白酶抑制剂(ASTI)的活性。急性肾小管损伤的早期阶段,ASTI活性显著升高,在组织学异常或血肌酐升高之前观察到这种变化。在实验性肾小球肾炎早期未观察到ASTI活性的改变。所得数据证实ASTI通过肾小管排出,血浆ASTI浓度对肾小管功能障碍非常敏感。
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