Clomipramine actions on firing rate in septal nuclei of the rat are not related to anaesthesia (urethane).

Boletin de estudios medicos y biologicos Pub Date : 1991-01-01

C M Contreras, M L Marván, H Lara-Morales, A Barradas, L Chacón, M A Guzmán-Sáenz, C Márquez Flores

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Abstract

An increased firing rate in lateral septal nuclei (LSN) appears in urethane-anesthetized rats after several acute drug and non-drug human antidepressant treatments. A still more pronounced increase in firing rate is produced in LSN after clomipramine (CMI) long-term treatment. In spite of urethane is a widely used anesthetic for single unit extracellular recordings, it modifies evoked potentials wave-form. Therefore, present study discards urethane interaction with CMI in LSN single unit extracellular recordings. CMI was acutely injected (1.25 mg/kg: IP) either to urethane-anesthetized, or non-anesthetized encephale-isolé rats. The CMI treated groups showed higher rates of firing in LSN regardless of the use of general anesthesia during recordings. Another group of urethane-anesthetized rats received intracerebroventricular (ICV) microinjections of CMI (100 micrograms/10 microliters/1 min). An amount of 42.8% of LSN-recorded neurons responded with a long-lasting increased firing rate. Results discard urethane and CMI interactions. Additionally, systemic actions of CMI on firing rate of LSN are reproduced by ICV/route microinjections.

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氯丙咪嗪对大鼠间隔核放电率的影响与麻醉(氨基甲酸乙酯)无关。

脲麻醉大鼠经多次急性药物和非药物人类抗抑郁治疗后，侧隔核(LSN)放电率增加。氯丙咪嗪(CMI)长期治疗后LSN的放电率增加更为明显。尽管氨基甲酸乙酯是一种广泛用于单细胞外记录的麻醉剂，但它会改变诱发电位波形。因此，本研究在LSN单单元胞外记录中抛弃了聚氨酯与CMI的相互作用。急性注射CMI (1.25 mg/kg: IP)给脲麻醉或未麻醉的脑隔离大鼠。CMI治疗组在记录过程中显示出更高的LSN放电率，无论是否使用全身麻醉。另一组经氨基脲麻醉的大鼠在脑室(ICV)内微注射CMI(100微克/10微升/1分钟)。42.8%的lsn记录的神经元有持续增加的放电率。结果摒弃了聚氨酯和CMI的相互作用。此外，通过ICV/路线显微注射重现了CMI对LSN发射速率的全身作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Boletin de estudios medicos y biologicos

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