[Perineural application of glycerol and phenol-glycerol. Histomorphologic-morphometric study].

Abstract

In a long-term study the effect of glycerol and phenol-glycerol on rats mandibular nerve was analysed. The substances were applicated perineurally. Nerves treated with glycerol did not show any severe pathological changes. Only the number of desintegrations of myelin seemed to be more pronounced. This, however, was a transitary effect. On the contrary, nerves treated with phenol-glycerol showed the familiar picture of degeneration and regeneration. According to our results it can be stated that the perineural application of glycerol has no toxic and destructive effect on the nerve. Therefore, the perineural glycerol blocking will not cause severe side-effects and the method can be recommended in the therapy of chronic facial pain.