{"title":"[Isolation of bone morphogenetic protein from human osteosarcoma tissue].","authors":"N Kübler, M R Urist","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Isolated from an osteosarcoma specimen from a 15-year-old girl and assayed by implantation, partly purified lyophilized bone morphogenetic protein (BMP) induced heterotopic ossification in the mouse quadriceps. The apparent molecular weight was 18 kDa. Osteosarcoma-derived BMP induced the same process of bone development as human BMP from normal bone matrix.</p>","PeriodicalId":77522,"journal":{"name":"Deutsche Zeitschrift fur Mund-, Kiefer- und Gesichts-Chirurgie","volume":"15 4","pages":"258-64"},"PeriodicalIF":0.0000,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Deutsche Zeitschrift fur Mund-, Kiefer- und Gesichts-Chirurgie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Isolated from an osteosarcoma specimen from a 15-year-old girl and assayed by implantation, partly purified lyophilized bone morphogenetic protein (BMP) induced heterotopic ossification in the mouse quadriceps. The apparent molecular weight was 18 kDa. Osteosarcoma-derived BMP induced the same process of bone development as human BMP from normal bone matrix.
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