THE INFLUENCE OF ROSEMARY ESSENTIAL OIL APPLIED PER OS ON THE PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES OF PARACETAMOL

Isidora Milanović, A. Rašković, S. Vukmirović, N. Stilinović, M. Mikov
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Abstract

Introduction: Rosemary essential oil can be used for treating dyspepsia, mild spasmodic disorders of thegastrointestinal tract, externally as analgetic in muscular and articular pain and minor peripheral circulatory disorders.It is important to explore its analgesic potential and its influence on the pharmacodynamic and pharmacokineticproperties of paracetamol. Methodology: Rosemary essential oil was applied to mice orally (doses: 10 and 20 mg/kgb.w.) for pharmacodynamic tests for seven days. Rats treated with rosemary essential oil for seven days orally (5 and10 mg/kg b.w.) were used for the examination of the influence of essential oil on the pharmacokinetic properties ofparacetamol (applied on the 7th day p.o. or i.v.). Pharmacokinetic parameters were analyzed in blood samples obtainedfrom rats' tail veins, with the HPLC method. Results: The essential oil of rosemary shows analgetic properties. Therosemary essential oil increases pharmacological effects of paracetamol and does not change paracetamolbioavailability. Conclusion: The herbal drugs could change the pharmacodynamic and the pharmacokinetic propertiesof classical drugs and they could also change the safety of classical drugs use in human population.
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迷迭香精油对扑热息痛药效学和药代动力学性质的影响
迷迭香精油可用于治疗消化不良,胃肠道的轻度痉挛性疾病,外用于肌肉和关节疼痛以及轻微的外周循环疾病。探讨其镇痛潜能及其对扑热息痛药效学和药代动力学特性的影响具有重要意义。方法:迷迭香精油以10、20 mg/kg .w的剂量口服小鼠,进行7 d的药理学试验。采用迷迭香精油(5、10 mg/kg b.w)给药7 d,观察精油对扑热息痛药代动力学特性的影响(第7天口服或静脉注射)。采用高效液相色谱法对大鼠尾静脉血样中的药动学参数进行了分析。结果:迷迭香精油具有镇痛作用。香迭香精油增加对乙酰氨基酚的药理作用,不改变对乙酰氨基酚的生物利用度。结论:中药可以改变经典药物的药效学和药动学性质,也可以改变经典药物在人群中的使用安全性。
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