{"title":"Effects of thymoxamine on corneal endothelium.","authors":"K Green, J M Chapman, L Cheeks, D S Hull","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We have investigated the effects of 0.02 and 0.2% thymoxamine hydrochloride on the isolated rabbit corneal endothelium. The corneal swelling rate, measured by specular microscopy, indicated that 0.02% thymoxamine caused a swelling rate equal to controls while a 0.2% concentration caused a significantly increased swelling rate (34.1 vs 10.3 microns/h; P less than 0.05). The data suggests that the maximum recommended intracameral concentration of thymoxamine be 0.02% in order to allow a 10-fold safety factor for the corneal endothelium.</p>","PeriodicalId":17964,"journal":{"name":"Lens and eye toxicity research","volume":"8 1","pages":"1-8"},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lens and eye toxicity research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
We have investigated the effects of 0.02 and 0.2% thymoxamine hydrochloride on the isolated rabbit corneal endothelium. The corneal swelling rate, measured by specular microscopy, indicated that 0.02% thymoxamine caused a swelling rate equal to controls while a 0.2% concentration caused a significantly increased swelling rate (34.1 vs 10.3 microns/h; P less than 0.05). The data suggests that the maximum recommended intracameral concentration of thymoxamine be 0.02% in order to allow a 10-fold safety factor for the corneal endothelium.
研究了0.02和0.2%盐酸百里香胺对离体兔角膜内皮的影响。通过镜面显微镜测量的角膜肿胀率表明，0.02%的百里香胺引起的肿胀率与对照组相同，而0.2%的浓度引起的肿胀率显著增加(34.1 vs 10.3微米/小时;P < 0.05)。数据表明，为了使角膜内皮的安全系数达到10倍，推荐的最大胸腺胺内窥镜浓度为0.02%。
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