Involvement of calcium ions in the modulation of electrically-induced rat vas deferens contractions by histaminergic drugs.

General pharmacology Pub Date : 1991-01-01 DOI:10.1016/0306-3623(91)90081-g

P Vassilev, V Mutafova-Yambolieva, D Staneva-Stoytcheva, S Todorov

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Abstract

1. The modulatory action of histaminergic drugs: histamine; 2-(2-aminoethyl)thiazole (H1-agonist); dimaprit (H2-agonist); diphenhydramine (H1-receptor antagonist); and cimetidine (H2-receptor antagonist) on rat vas deferens contractions induced by electrical field stimulation (0.1 Hz, 1 pulse, 1 msec duration, supramaximal voltage) was studied either at different calcium concentrations in the nutrient fluid or after verapamil. 2. Histamine and 2-(2-aminoethyl)thiazole inhibited the electrically-evoked contractions (EEC). This effect was unchanged after verapamil. 3. Diphenhydramine potentiated the EEC. Verapamil added before the H1-receptor antagonist inhibited this action. 4. The effects of agonists and antagonists of H-receptors decreased with the increasing of calcium concentration. 5. The results obtained suggested the existence of heterogeneity of prejunctional H-receptors. The function of histaminergic drugs on adrenergic neurotransmission in field stimulated rat vas deferens is Ca(2+)-dependent.

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钙离子参与组胺能药物对电诱导大鼠输精管收缩的调节。

1. 组胺能药物的调节作用:组胺;(2) - 2-aminoethyl噻唑(H1-agonist);dimaprit (H2-agonist);苯海拉明(h1受体拮抗剂);研究了电场刺激(0.1 Hz, 1次脉冲，1毫秒持续时间，最高电压)对大鼠输精管收缩的影响，以及不同钙浓度营养液和维拉帕米后的影响。2. 组胺和2-(2-氨基乙基)噻唑抑制电诱发收缩(EEC)。维拉帕米后这种效果没有改变。3.苯海拉明增强了欧共体。在h1受体拮抗剂之前加入维拉帕米抑制了这种作用。4. h受体激动剂和拮抗剂的作用随钙浓度的增加而减弱。5. 结果表明，膜前h受体存在异质性。组胺类药物对场刺激大鼠输精管肾上腺素能神经传递的作用是Ca(2+)依赖的。

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General pharmacology

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