MDR1 gene expression and prognostic factors in primary breast carcinomas

Josef Wallner , Dieter Depisch , Martina Hopfner , Karin Haider , Jürgen Spona , Heinz Ludwig , Robert Pirker
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引用次数: 51

Abstract

To prospectively assess the role of the MDR1 gene in breast carcinomas, MDR1 RNA levels of breast carcinoma specimens were determined by slot blot analysis. In 59 evaluable patients with primary breast carcinomas, MDR1 RNA levels of the carcinomas were negative in 54%, low in 29% and high in 17% of the patients. No differences in age, menopause status, oestrogen and progesterone receptor levels, tumour size, lymph node involvement and c-erbB-2/neu gene expression were observed between MDR1 RNA negative patients and MDR1 RNA positive patients.

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MDR1基因在原发性乳腺癌中的表达及预后影响因素
为了前瞻性地评估MDR1基因在乳腺癌中的作用,我们采用凹槽印迹分析方法测定乳腺癌标本中MDR1 RNA的水平。在59例可评估的原发性乳腺癌患者中,54%的乳腺癌患者的MDR1 RNA水平为阴性,29%的患者为低水平,17%的患者为高水平。MDR1 RNA阴性患者和MDR1 RNA阳性患者在年龄、绝经状态、雌激素和孕激素受体水平、肿瘤大小、淋巴结累及程度和c-erbB-2/neu基因表达方面均无差异。
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