Impact of neonatal benzpyrene pretreatment (imprinting) on the hepatic 3H-benzpyrene intake and output in adult rat liver. Investigation into the hepatic localization of benzpyrene in adult rats.

Abstract

One hour after treatment with 3H-benzpyrene, grains appeared for the most part above the hepatocellular surface, heterochromatin and dense vacuoles, whereas 24 h later they were associated mainly with the dense vacuoles and smooth-surfaced endoplasmic reticulum and only, a few were still present above the heterochromatin. Neonatal pretreatment (imprinting) with benzpyrene accounted for an earlier appearance of benzpyrene in the hepatocytes relative to the non-pretreated control, but while labelled benzpyrene had practically disappeared from the liver of imprinted rats within 24 h, it still persisted in the liver of control rats at a level approximating the 4 h value.