[Changes in the cytoarchitectonics of the rat thymus at different times after body exposure to dimethyl sulfate].

Abstract

Change in cytoarchitectonics of the organ at different terms after the action of dimethylsulfate (DMS) vapour on the organism was studied by a morphometrical method in histological preparations of the thymus of albino Wistar rats. The thymus was found to intimately react to DMS. On the 1st day after treatment the lymphocytopoietic function was suppressed, the process of destruction of cells in the organs was intensified, the amount of macrophages and plasma cells was increased. Two weeks after cessation of the treatment the organs became activated: intensified cell proliferation and less disintegration of lymphocytes were noted. However no complete reestablishment of the cell ratio took place even 3 months after cessation of the treatment.