Molecular biology of the vascular renin-angiotensin system.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158864
N J Samani, J D Swales
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引用次数: 17

Abstract

Considerable evidence has been accumulated for a renin-angiotensin system in the blood vessel wall with local generation of both angiotensin I and angiotensin II that plays an important role in blood pressure regulation. A major source for vascular renin is renal renin taken up by the arterial wall from the circulation. However, recent studies suggest that, in addition, local synthesis of components of the renin-angiotensin cascade also takes place in the vessel wall. The contribution that these locally derived components make to the functions of the vascular renin-angiotensin system remains to be elucidated. Studies, particularly in vitro, suggest that vascular pathways for angiotensin generation not involving renin or angiotensin-converting enzyme may also exist. As in the case of the locally derived components of the renin-angiotensin cascade, the role of these alternate pathways in the physiology of the vascular wall remain to be defined.

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血管肾素-血管紧张素系统的分子生物学。
大量证据表明,肾素-血管紧张素系统存在于血管壁上,局部生成血管紧张素I和血管紧张素II在血压调节中起重要作用。血管肾素的主要来源是由动脉壁从循环中吸收的肾素。然而,最近的研究表明,肾素-血管紧张素级联成分的局部合成也发生在血管壁上。这些局部衍生成分对血管肾素-血管紧张素系统功能的贡献仍有待阐明。研究,特别是体外研究,表明血管紧张素生成的血管途径不涉及肾素或血管紧张素转换酶也可能存在。就肾素-血管紧张素级联的局部衍生成分而言,这些替代途径在血管壁生理学中的作用仍有待确定。
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