Cell biology of atrial natriuretic peptide.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158847
C Huot, J Tremblay, P Hamet
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引用次数: 6

Abstract

Atrial natriuretic peptide (ANP) exhibits a wide spectrum of cardiovascular, endocrine, metabolic and renal actions. cGMP is the major mediator of ANP at the cellular level and only tissues possessing particulate guanylate cyclase appear to present ANP-induced actions. Three types of ANP receptors have recently been cloned. Two of them (A and B receptors) are homologous and contain guanylate cyclase catalytic domains. The C receptor could possibly regulate the metabolic fate of ANP. Data obtained by the radiation inactivation method suggest the presence of an inter- or intramolecular inhibitory component of nearly 90 kilodaltons that represses the catalytic activity of guanylate cyclase within its membrane environment. The mechanism of guanylate cyclase stimulation by ANP could involve this inhibitory component. Preliminary data suggest that the hyperresponsiveness of the particulate guanylate cyclase/cGMP system in hypertension occurs through modulation of the inhibitory component.

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房利钠肽的细胞生物学。
心房利钠肽(ANP)具有广泛的心血管、内分泌、代谢和肾脏作用。在细胞水平上,cGMP是ANP的主要介质,只有含有颗粒鸟苷酸环化酶的组织才表现出ANP诱导的作用。最近已经克隆了三种类型的ANP受体。其中两个(A和B受体)是同源的,并且含有鸟苷酸环化酶催化结构域。C受体可能调控ANP的代谢命运。通过辐射失活方法获得的数据表明,存在近90千道尔顿的分子间或分子内抑制成分,抑制了鸟苷酸环化酶在其膜环境中的催化活性。ANP刺激鸟苷酸环化酶的机制可能与这种抑制成分有关。初步数据表明,颗粒鸟苷酸环化酶/cGMP系统在高血压中的高反应性是通过抑制成分的调节发生的。
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