Interaction of vascular alpha-1 adrenoceptors with multiple signal transduction pathways.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158851
R R Ruffolo, A J Nichols, M A Oriowo
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引用次数: 8

Abstract

In the rat vasculature, a single alpha 1-adrenoceptor may be coupled to two distinct G proteins, one of which regulates phospholipase C activity and is insensitive to pertussis toxin, and another which regulates calcium channel function and is highly sensitive to inhibition by pertussis toxin. alpha 1-Adrenoceptor agonists may in theory activate both pathways, but the efficiency of alpha 1-adrenoceptor coupling to the pertussis-toxin-insensitive pathway is low relative to the other pathway that couples the alpha 1-adrenoceptor to calcium channels. As such, only full agonists with high intrinsic efficacy can activate both pathways, whereas partial agonists, by virtue of their lower intrinsic efficacies, are less able to activate the pertussis-toxin-insensitive pathway, thereby rendering partial alpha 1-adrenoceptor agonists more sensitive than full alpha 1-adrenoceptor agonists to inhibition by calcium channel blockers and pertussis toxin.

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血管α -1肾上腺素受体与多种信号转导途径的相互作用。
在大鼠脉管系统中,单一α 1-肾上腺素能受体可能与两种不同的G蛋白偶联,其中一种调节磷脂酶C活性,对百日咳毒素不敏感,另一种调节钙通道功能,对百日咳毒素的抑制高度敏感。α 1-肾上腺素能受体激动剂理论上可以激活这两种途径,但α 1-肾上腺素能受体偶联到百日咳-毒素不敏感途径的效率相对于α 1-肾上腺素能受体偶联到钙通道的其他途径低。因此,只有具有高内在功效的完全激动剂才能激活这两种途径,而部分激动剂由于其较低的内在功效,激活百日咳-毒素不敏感途径的能力较低,因此使得部分α 1-肾上腺素受体激动剂比完全α 1-肾上腺素受体激动剂对钙通道阻滞剂和百日咳毒素的抑制更敏感。
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