Opioid Prescription Trends for Isolated Diaphyseal Femur Fractures in Pediatric Patients

Jennifer N Grauberger, D. Larson, A. Stans, W. Shaughnessy, A. Larson, T. Milbrandt
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Abstract

Purpose: Despite the ongoing opioid epidemic, there is a lack of research on narcotic prescribing in the pediatric orthopaedic population. The Pediatric Orthopaedic Society of North America (POSNA) therefore published a survey on pain management to provide recommendations for opioid dosing. The goal of this study was to characterize opioid prescribing patterns for pediatric femur fractures in the context of the opioid epidemic and emerging national studies/guidelines. Methods: A retrospective review of 128 pediatric patients (age < 16) with isolated diaphyseal femur fractures was conducted between 2003-2019 at a level I pediatric trauma center. Comparison groups included before distribution of the POSNA survey (pre-POSNA = 01/01/2016 or earlier, N = 85) and after the survey (post-POSNA, N = 43). Results: Median total hospital post-operative opioids prescribed was 27.2 morphine milligram equivalents (MME). The two groups differed in: age (pre-POSNA = 9.0 years, post-POSNA =3.7 years, P =0.0381), hospital length of stay (LOS) (pre-POSNA = 2 days, post-POSNA =1 day, P < 0.0001), and procedural incision required for fracture reduction (pre-POSNA = 28.3%, post-POSNA = 58.1%, P = 0.0019). Adjusted post-operative opioid dosing was significantly lower post-POSNA (median reduction of 18.351 MME per year, P = 0.0408). Conclusions: The period following the POSNA survey was associated with a significant decline in post-operative narcotic prescriptions for pediatric femur fractures. The timing of the survey likely represents an increased concern for pediatric opioid use and a shift in clinical practice. Further work is needed to optimize injury and patient-specific narcotic prescribing.
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小儿孤立性股骨骨干骨折的阿片类药物处方趋势
目的:尽管阿片类药物持续流行,但缺乏对儿科骨科人群麻醉处方的研究。因此,北美儿科骨科学会(POSNA)发表了一项关于疼痛管理的调查,为阿片类药物的剂量提供建议。本研究的目的是在阿片类药物流行和新兴国家研究/指南的背景下,描述儿童股骨骨折的阿片类药物处方模式。方法:回顾性分析某一级儿科创伤中心2003-2019年收治的128例(年龄< 16岁)孤立性股骨骨干骨折患儿。对照组包括发放POSNA调查前(POSNA前= 2016年1月1日或之前,N = 85)和发放POSNA调查后(POSNA后,N = 43)。结果:医院术后阿片类药物处方的中位数为27.2吗啡毫克当量(MME)。两组患者的年龄(posna前= 9.0岁,posna后=3.7岁,P =0.0381)、住院时间(LOS) (posna前= 2天,posna后=1天,P < 0.0001)和骨折复位所需的手术切口(posna前= 28.3%,posna后= 58.1%,P = 0.0019)存在差异。posna后调整后的术后阿片类药物剂量显著降低(中位数减少18.351 MME /年,P = 0.0408)。结论:POSNA调查后的一段时间与儿童股骨骨折术后麻醉处方的显著下降有关。调查的时机可能代表了对儿科阿片类药物使用的日益关注和临床实践的转变。需要进一步的工作来优化损伤和患者特定的麻醉处方。
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