Load balancing: a case study of a pharmaceutical drug candidate database

Zina Ben-Miled, S. Li, Jesse Martin, Chavali Balagopalakrishna, O. Bukhres, Robert J. Oppelt
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Abstract

In the past decade chemical and biological laboratory experiments have generated an explosive amount of data. As a result, a set applications that manipulate these dynamic, heterogeneous and massive amounts of data have emerged. An example of such applications in the pharmaceutical industry is the computational process involved in the early drug discovery of lead drug candidates for a given target disease. The discovery of lead drug candidates requires both consecutive and random data access to the pharmaceutical drug candidate database. This paper focuses on performance enhancement techniques for the pharmaceutical drug candidate database application. In particular, this paper compares static load balancing and dynamic load balancing in the context of the drug candidate database application. This database application is based on multi-queries. Some of these queries are multi-join queries.
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负载平衡:一个药物候选数据库的案例研究
在过去的十年里,化学和生物实验室实验产生了爆炸性的数据量。因此,出现了一组处理这些动态、异构和海量数据的应用程序。这种应用在制药工业中的一个例子是针对给定目标疾病的先导候选药物的早期药物发现所涉及的计算过程。先导候选药物的发现需要对候选药物数据库进行连续和随机的数据访问。本文主要研究候选药物数据库应用的性能增强技术。本文特别对候选药物数据库应用中的静态负载平衡和动态负载平衡进行了比较。这个数据库应用程序基于多查询。其中一些查询是多连接查询。
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