Ecological evidence for later dementia diagnosis in areas with higher rates of bilingualism: Evidence fromY Fro Gymraegin Wales

Christopher W. N. Saville, C. Patterson, Rhian Russell Owen, Joanne Kelly-Rhind
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Abstract

Bilingualism has been proposed as a protective factor against dementia, putatively delaying onset by several years. However, evidence is equivocal. One possibility is that the pattern of confounding varies across contexts, with confounders such as socioeconomic status, rurality, and migrant status being positively associated with bilingualism in some settings and negatively in others. The present study examines this in Welsh-speaking Wales, where the confounding structure differs from much of the literature.Routine clinical data from the Memory Clinic service covering the counties of Gwynedd and Ynys Môn were used to examine the ecological correlation between Welsh-speaking rates and dementia diagnosis rates by lower super output area. Analyses were conducted using Poisson generalised linear mixed effects models with spatial auto-correlation terms.A total of 404 cases were identified. No overall association was observed between dementia diagnosis rates and Welsh-speaking rates, but the association was moderated by age band, such that Welsh-speaking rates were protective in 65–74 year-olds but a risk factor in 75+ year olds (rate ratio=.71, .53-.94). This was robust to adjustment for area-level poverty.Although causation cannot be inferred, the findings are consistent with bilingualism delaying dementia onset. Welsh-English bilingualism provides a useful complement to research on this topic elsewhere in the world, as the confounding structure is unusual.
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双语率较高地区晚期痴呆诊断的生态证据:来自威尔士金格拉津的证据
双语能力被认为是预防痴呆症的一个保护因素,可以将发病时间推迟几年。然而,证据并不明确。一种可能性是,混杂因素的模式因环境而异,社会经济地位、农村生活和移民身份等混杂因素在某些情况下与双语能力呈正相关,在其他情况下则呈负相关。本研究在讲威尔士语的威尔士考察了这一点,那里的混淆结构与许多文献不同。来自记忆诊所服务的常规临床数据覆盖Gwynedd和Ynys Môn县,用于通过较低的超输出区域检查威尔士语率和痴呆诊断率之间的生态相关性。使用带空间自相关项的泊松广义线性混合效应模型进行分析。共发现404例病例。在痴呆诊断率和讲威尔士语率之间没有观察到总体的关联,但这种关联因年龄组而有所缓和,例如,讲威尔士语率对65-74岁的人有保护作用,但对75岁以上的人有危险因素(比率比=)。71 .53点总收入)。这对地区贫困水平的调整是强有力的。虽然因果关系无法推断,但研究结果与双语延迟痴呆发病一致。威尔士-英语双语为世界其他地方对这一主题的研究提供了有益的补充,因为混淆结构是不寻常的。
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