Study of DNA nanoparticle manipulation using atomic force microscopy based on finite element method using theories of contact mechanics

Abstract

using microscopy based on element method using Nanoparticle manipulation is a process in which particles are moved on a micro/ nanoscale scale using an atomic force microscope and has a wide range of applications from component production to the medical world. In this study, using the theories of contact mechanics of Hertz, JKR, DMT and BSP, as well as using the structure of the DNA biological cell using the Elman method using ABAQUS software to study the amount of displacement, acceleration, force, stress and velocity in time The DNA molecule is discussed on a base sheet and the factors that affect them. The results show that in the deformation between the target particles and the spherical tip of the needle, the Hertz model showed the least and the JKR model showed the highest deformation and penetration depth. By increasing the angle of the needle tip with the z-axis, the amount of penetration depth and deformation created between the particle and the base plate is reduced. Also, the graph of changes in each of the studied parameters of the effective factors per 20 μm of displacement and 20 milliseconds of time for the DNA manipulation process has been calculated.