Retrospective evaluation of brain metastates in lung cancer patients treated with stereotactic radiosurgery alone

Abstract

INTRODUCTION: Due to new systemic treatment modalities, overall survival in lung cancer is increasing. Incidence of brain metastases in lung cancer are more common for this reason. The utilisation of stereotactic radiosurgery for one and oligo (two-four) brain metastases, has provided this treatment strategy as a promt treatment alternative. In this study we aimed to investigate the efficiency of stereotactic radiosurgery in lung cancer patients with brain metastasis, the effectiveness of adding diffusion magnetic resonance imaging (MRI) to conventional MRI for treatment evaluation and the relationship between clinical parameters retrospectively. METHODS: Seventy-nine lung cancer patients treated between January 2016 and December 2017 in our clinic with stereotactic radiosurgery whose eastern cooperative oncology group (ECOG) performance status were 0-1 and had less than 5 brain metastases, has retrsopectively analysed. RESULTS: The median age of patients was 59 years (43-78). Diffusion MRI has provided no more benefit for evaluation of treatment. There was no statistically significant mortality difference between subgroups of small cell and non small cell lung carcinoma. The presence of extracranial metastases has shortened the overall survival time significantly (p=0,042). DISCUSSION AND CONCLUSION: The lung cancer patients with brain metastases have histopathological and genetic heterogenity. Multivariate analysis showed the presence of extracranial metastases had only unfavorable impact on overall survival in our study. Orijinal Çalışma 204 Adress for correspondence: Dr. Öğr. Üyesi Serkan Değirmencioğlu, Pamukkale Üniversitesi Hastanesi Fahri Gökşin Onkoloji Merkezi Üniversite sokak no: 7 Bağbaşı 20160 Denizli Türkiye e-mail: sdegirmencioglu@pau.edu.tr Available at www.actaoncologicaturcica.com Copyright ©Ankara Onkoloji Hastanesi