Comparison of total Intravenous Ketamine and Propofol Anaesthesia in Acepromazine-Dexmedetomidine sedated cats

Abstract

Total intravenous anaesthesia (TIVA) refers to the induction and maintenance of general anaesthesia with drugs administered solely by the intravenous (IV) route. Presently, ketamine and propofol are popular and in use for TIVA in small animals. This study compared ketamine and propofol anaesthesia in cats premedicated with acepromazine-dexmedetomidine combination. Six indigenous Nigerian local cats were premedicated with intramuscular injection of acepromazine (0.2mg/kg) and dexmedetomidine (40µg/kg) mixture, followed by induction of anesthesia with either bolus propofol (1mg/kg) or ketamine (0.5mg/kg) IV 20 min later. Maintenance of anesthesia for 2h was achieved with continous fluid administration using dose of 0.5ml/8ml and 0.05ml/8ml in lactated Ringers solution for propofol and ketamine respectively. One week space was allowed between protocols in the crossover experiment.