Dual-band terahertz biosensor based on metamaterial absorber

Huan Liu, Jing Ma, Gui-Min Chen, Hai-Ling He, Ya-Xian Fan, Z. Tao
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Abstract

Traditional biological detection methods in practical applications, such as polymerase chain reaction, fluorescence microscopy, flow cytometry and so on, are commonly limited by label needed, high cost, complex operation, low sensitivity. Fortunately, metamaterial-based terahertz (THz) biosensors have shown great potential in label-free, integrated chip and ultra-sensitive sensing due to their advantages in light collection and miniaturization. However, most of THz metamaterial biosensors are based on transmission spectrum measurement, the one-way transmission will lead to the weak interactions between analyte and THz wave, so the sensitivity will be greatly reduced. Here, we proposed a label-free dual-band THz biosensor with ultra-high sensitivity based on metamaterial absorber. The device consists of the asymmetric cross shaped metal metasurface, hollow sensing channel and a back reflector. The simulation results show that the two resonance modes are excited at 0.626 THz and 1.504 THz and the absorptivity is higher than 95%. With the increasing the refractive index of the analyte, the two absorption peaks have obvious red shift. The maximum sensitivities for mode A and mode B are up to 250 GHz/RIU and 630 GHz/RIU, respectively. By simulating the electromagnetic field distribution of the structure, the absorption sensing mechanism is discussed in detail. The proposed THz metamaterial biosensor exhibits promising applications in chemical and biological detection.
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基于超材料吸收体的双频太赫兹生物传感器
在实际应用中,传统的生物检测方法,如聚合酶链反应、荧光显微镜、流式细胞术等,通常受到需要标记、成本高、操作复杂、灵敏度低等限制。幸运的是,基于超材料的太赫兹(THz)生物传感器由于其在光收集和小型化方面的优势,在无标签、集成芯片和超灵敏传感方面显示出巨大的潜力。然而,大多数太赫兹超材料生物传感器都是基于透射光谱测量,单向传输会导致分析物与太赫兹波之间的弱相互作用,因此灵敏度会大大降低。在此,我们提出了一种基于超材料吸收剂的超高灵敏度无标签双频太赫兹生物传感器。该装置由非对称十字形金属超表面、空心传感通道和后反射器组成。仿真结果表明,两种谐振模式分别在0.626 THz和1.504 THz激发,吸光率均大于95%。随着分析物折射率的增加,两个吸收峰有明显的红移。A模式和B模式的最大灵敏度分别可达250 GHz/RIU和630 GHz/RIU。通过模拟结构的电磁场分布,详细讨论了吸收传感机理。所提出的太赫兹超材料生物传感器在化学和生物检测方面具有广阔的应用前景。
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