Haemostasis and thrombosis

Abstract

This chapter discusses the models of coagulation and the factors that promote blood-clot formation, counter-balanced by the factors that switch the system off. It then provides a clinical assessment of bleeding problems, and laboratory investigations that can be used. Neonatal haemostatis is discussed, and then various specific disorders including haemophilia A and B, von Willebrand disease, and various other factor deficiencies are outlined. Inherited platelet disorders, problems with fibrinogen, and haemorrhagic disease of the newborn are all covered. The chapter then goes on to describe thrombosis in childhood, its treatment, neonatal thrombosis, complications, and anticoagulation in children.