A Modular Approach to Heterogeneous Biochemical Model Simulation on an FPGA

H. Yamada, Yasunori Osana, Tomoya Ishimori, Tomonori Ooya, Masato Yoshimi, Yuri Nishikawa, Akira Funahashi, N. Hiroi, H. Amano, Yuichiro Shibata, K. Oguri
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引用次数: 1

Abstract

Mathematical modeling and simulation of cellular systems are important processes in modern life science, to understand the behavior of life as a system. Kinetic model of a biochemical pathways is described as an ordinary differential system, consists of a variety of equations to represent velocity of corresponding chemical reactions. This paper describes a modular and automated approach to synthesize a custom HDL module for given biochemical model, that enables to build an optimal circuit to accelerate its simulation within a limited resource of an FPGA. As the result of evaluation, this method achieved reduction of logic usage by 10-60% while the overheads in frequency and pipeline depth is remaining about 10%.
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基于FPGA的异构生化模型仿真模块化方法
细胞系统的数学建模和模拟是现代生命科学中理解生命作为一个系统的行为的重要过程。一个生化途径的动力学模型被描述为一个常微分系统,由表示相应化学反应速度的各种方程组成。本文描述了一种模块化和自动化的方法来合成一个定制的HDL模块为给定的生化模型,使建立一个最佳电路,以加速其仿真在有限的FPGA资源。评估结果表明,该方法减少了10-60%的逻辑使用,而频率和管道深度的开销保持在10%左右。
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