Anisimova OYu, E A Volynskaya, T I Kuzmina, A B Danilevich
{"title":"Dynamic model of 99mTc-labelled lipoprotein accumulation in rabbit liver.","authors":"Anisimova OYu, E A Volynskaya, T I Kuzmina, A B Danilevich","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>To create a mathematical model to describe the receptor-mediated accumulation of 99mTc-labelled lipoproteins in rabbit liver, a set of differential equations was devised for the simplest case: that involving one ligand and one receptor. Normal and hypercholesterolemic rabbits were included in gammascintigraphic trials as having normal and reduced numbers, respectively, of liver low-density lipoprotein (LDL) receptors. The system described may have clinical applications as a quick and effective method of assessment of LDL uptake by the liver.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 1","pages":"45-8"},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical science","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
To create a mathematical model to describe the receptor-mediated accumulation of 99mTc-labelled lipoproteins in rabbit liver, a set of differential equations was devised for the simplest case: that involving one ligand and one receptor. Normal and hypercholesterolemic rabbits were included in gammascintigraphic trials as having normal and reduced numbers, respectively, of liver low-density lipoprotein (LDL) receptors. The system described may have clinical applications as a quick and effective method of assessment of LDL uptake by the liver.
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