[Regular Paper] Texture Biomarkers of Alzheimer's Disease and Disease Progression in the Mouse Retina

Abstract

In this paper, we imaged the retina of wild-type and the triple-transgenic mouse model of Alzheimer’s disease (3xTg- AD) with optical coherence tomography to assess changes in the retinal tissue associated with the Alzheimer’s disease. Texture analysis allowed to identify differences between groups at the age of four months, and to find biomarkers of disease progression. Furthermore, our findings suggest that specific layers of the retina may play a fundamental role in the assessment of early changes associated with the Alzheimer’s disease.