Study on usage and evaluation of stevioside as sweetening agent in salbutamol sulphate and Bromhexine hydrochloride syrups

Abstract

Stevioside is an intense sweetener ideally suited for liquid oral dosage forms such as Syrups, Dry syrups and suspensions. In the study syrups were prepared using stevioside as sweetener in 0.5 and 1% w/v concentration, salbutamol sulphate and Bromhexine hydrochloride in combination as model drugs. The usage of stevioside can offer many advantages to patients suffering from Diabetes, Phenylketonurea and calorie conscious, ranging from pediatrics to geriatrics. If the sweetener is soluble in the solvent, concentration of stevioside required is less i.e. up to 0.5% w/v. Formulated liquid oral dosage forms were stable at room temperature and showed good sweetness and palatability and were evaluated for drug content, viscosity, pH, and compatibility studies. Evaluation of the sweeteners and palatability was done using a panel of trained volunteers and it was observed that concentration of 0.5% w/v of Stevioside showed good sweetness and palatability.