Evaluation of relationship between hyperuricemia and hyperhomocysteinemia

Abstract

Aims: Hyperuricemia is generally a subclinical disorder. Uric acid takes part in the malignities, obesity-insulin resistance syndrome, and some other cardiovasculer problems. Plasma homocysteine (Hcy) levels are one of the major risk factors of coronary heart disease, one of the major reasons of adult mortality. In this study, it was aimed to determine relationship between hyperuricemia and hyperhomocysteinemia. Methods: In this prospective research, 32 patients and 32 healthy controls were investigated. The age, sex, height, weight, complaints, medications and arterial blood pressure of the patients were measured and recorded. Moreover, whole blood test, fasting plasma glucose, serum lipids, sedimentation, cobalamin, folate, plasma total Hcy and uric acid levels were determined. Results: In the patient group 62.51% was male and 37.5% was female. The mean age was 54.69+12.03. In the healthy controls 62.5% was male and 37.5% was female, and the mean age was 51.59+9.57. The difference between the mean ages of both groups was not significant (p>0.05). Uric acid levels were found to be 8.61±0.98 mg/dl in the patient group and 4.09±0.99 mg/dl in the control group, and this difference was significant (p<0.001). Hcy levels were found to be 10.99+1.42 µmol/L in the patient group and 6.67±0.80 gmoI/L in the control group. This difference was also statistically significant (p<0.001) Conclusion: Hyperuricemia which is generally a subclinical disorder is accepted a coronary risk factor with the presence of other risks. Elevated plasma homocysteine is an independent risk factor for coronary heart disease. There are similar features of the both etiologia. Therefore we recommend to calculate the plasma homocysteine levels in hyperuricemic patients who have the risk of coronary heart disease and to treat the hyperuricemic patients having hyperhomocysteinemia and coronary risk factors.