A Review on Antibiotic Resistance in Microorganisms

Y. Jassim
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Abstract

Antibiotic resistance occurs when microorganisms develop mechanisms that protect them from the effects of antibiotics. Resistant microorganisms are more difficult to treat, require higher doses or alternative therapies may be more toxic, as well as more expensive. Microorganisms that are able to resist many antibiotics are called multi-resistant. All kinds of microorganisms can develop this ability to resist; Fungi develop resistance against antifungals, viruses develop resistance against antivirals, protozoa develop resistance against protozoa, and bacteria develop resistance against antibiotics. Resistance arose naturally either through genetic mutations or through the transmission of resistance from one sex that has acquired it to another that has not yet acquired it, in particular. Accordingly, it is urgent to reduce the misuse of antibiotics by not using them only when they are really needed.
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微生物抗生素耐药性研究进展
当微生物发展出保护它们免受抗生素影响的机制时,就会产生抗生素耐药性。耐药微生物更难治疗,需要更高的剂量,或者替代疗法可能毒性更大,也更昂贵。能够抵抗多种抗生素的微生物被称为多重耐药微生物。各种微生物都能发展出这种抵抗能力;真菌对抗真菌药物产生耐药性,病毒对抗病毒药物产生耐药性,原生动物对原生动物产生耐药性,细菌对抗生素产生耐药性。特别是通过基因突变,或者通过从一种性别获得的抗性传播到另一种性别尚未获得的抗性,自然产生了抗性。因此,迫切需要减少抗生素的滥用,只有在真正需要时才使用抗生素。
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