Effects of buflomedil on microvascular disorders in diabetic patients.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158919
C Le Dévéhat, M Vimeux, G Bondoux, T Khodabandehlou
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引用次数: 4

Abstract

The aim of this work was to evaluate the effect of buflomedil on hemorheologic, hemodynamic and microcirculatory properties in diabetic patients. Patients were 20 noninsulin-dependent diabetics with distal arteriopathy characterized by chronic hypoxia (transcutaneous oxygen pressure = 25.2 +/- 4.8 mm Hg). They were randomly assigned to two groups for a double-blind study versus placebo. The treatment consisted of a 4-hour intravenous perfusion of 400 mg of buflomedil or placebo as a daily dose during 7 days. Results showed significant improvements in hemodynamic parameters such as post-occlusive peak flow and time to peak flow at the end of buflomedil treatment. In the same manner, the transcutaneous oxygen pressure was found to be significantly increased after buflomedil treatment, whereas there was no modification by placebo. Indeed, red cell aggregation was significantly less important as a result of buflomedil treatment whilst red cell deformability was found to be significantly increased. These hemorheological improvements make the blood flow redistribution through the microcirculatory network easier and lead ultimately to better tissue oxygenation.

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丁咯地尔对糖尿病患者微血管病变的影响。
本研究旨在评价丁咯地尔对糖尿病患者血液流变学、血流动力学和微循环特性的影响。患者为20例非胰岛素依赖型糖尿病,远端动脉病变以慢性缺氧为特征(经皮氧压= 25.2 +/- 4.8 mm Hg)。他们被随机分为两组,分别进行双盲研究和安慰剂研究。治疗包括4小时静脉灌注400mg buflomedil或安慰剂作为每日剂量,持续7天。结果显示血流动力学参数有显著改善,如闭塞后峰值流量和丁氟地尔治疗结束时到达峰值流量的时间。以同样的方式,经皮氧压发现丁氟地尔治疗后显著增加,而安慰剂没有改变。事实上,由于丁氟地尔治疗,红细胞聚集的重要性明显降低,而红细胞的可变形性被发现显著增加。这些血液流变学的改善使血液更容易通过微循环网络重新分配,最终导致更好的组织氧合。
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Contractile and morphologic properties of a saphenous vein after 12 years as an aortocoronary bypass graft. Effect of H-8, an isoquinolinesulfonamide inhibitor of cyclic nucleotide-dependent protein kinase, on cAMP- and cGMP-mediated vasorelaxation. Hemorheological effects of buflomedil: action on shape and functions of the human neutrophils. Norepinephrine, phentolamine and buflomedil influence on arteriolar vasomotion in the hamster skinfold preparation. Heme-dependent activation of guanylate cyclase by nitric oxide: a novel signal transduction mechanism.
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