Comparison Pai-1 Level in Type 2 Diabetes Mellitus with and Without Diabetic Foot Ulcer

Alfi Dewi Sholat, D. Gatot, Savina Handayani, A. I. Mardia, S. Syafril
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Abstract

In type 2 diabetes mellitus, there are changes in hemostasis components, including overexpression of PAI-1. By these facts, the authors are interested in conducting the study of PAI-1 level in diabetic patients with and without foot ulcer. Methods: The sample of this research was collected cross-sectionally on 20 type 2 diabetic patients with foot ulcer and 20 without foot ulcer. Blood samples were taken to measure serum PAI-1 level, complete blood count and hemostasis screening test. Results: Statistical analysis showed there are significant differences in hemoglobin, trombosit, Fibrinogen and D-dimer levels in the ulcer and non-ulcer groups but no significant difference in PAI-1 level. Conclusions: No higher PAI – 1 level were found in diabetic foot ulcer group than those without diabetic foot ulcer. There was no significant difference between PAI-1 level and grade of diabetic foot ulcer.
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2型糖尿病合并与不合并糖尿病足溃疡患者Pai-1水平的比较
在2型糖尿病中,止血成分发生变化,包括PAI-1的过表达。基于这些事实,作者有兴趣对伴有和不伴有足部溃疡的糖尿病患者进行PAI-1水平的研究。方法:横断面采集20例伴有足部溃疡的2型糖尿病患者和20例无足部溃疡的2型糖尿病患者。取血检测血清PAI-1水平、全血细胞计数及止血筛查试验。结果:经统计学分析,溃疡组与非溃疡组血红蛋白、凝血蛋白、纤维蛋白原、d -二聚体水平差异有统计学意义,PAI-1水平差异无统计学意义。结论:糖尿病足溃疡组PAI - 1水平未高于非糖尿病足溃疡组。PAI-1水平与糖尿病足溃疡程度无显著性差异。
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