Coriocarcinoma testicular con metástasis a coroides

A. Cumming , J. Balanzario-Cuevas , J. Vitar-Sandoval , J. Monjaras-Guerra , J. Rodríguez-Robles , I. Cortés-Tapia , G. Regalado-Porras , E. Blancas , V.E. Corona-Montes
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Abstract

Introduction

Testicular tumors make up close to 1% of malignant tumors in men and 6% of the patients present with the disease between the ages of 20 and 35 years. Choriocarcinoma is a highly metastatic malignant tumor derived from undifferentiated trophoblasts. Ocular involvement in testicular tumors is extremely rare and occurs in 0.2% of cases.

Materials and methods

A 23-year-old man's disease symptoms began with intense headache associated with visual disturbances in the left eye and vertigo. He was referred to the Urology Department due to an enlarged left testis with a hardened consistency. Choriocarcinoma of the testis with metastases to the choroid, lung, and central nervous system was reported. After a cycle of chemotherapy, the patient presented with rapid deterioration of his vital functions and died in the intensive care unit. The pathology report stated metastatic testicular choriocarcinoma.

Discussion

Eighteen cases have been reported worldwide and the majority had very poor outcome. Prognosis in these cases was poor until the introduction of cisplatin-based chemotherapy in 1970. Choriocarcinoma is an aggressive variant of testicular carcinoma and has a high metastatic potential. Despite its hematogenous spread, it rarely metastasizes to the choroid.

Conclusions

Choriocarcinoma is an aggressive strain of testicular carcinoma with rapid hematogenous dissemination. Metastasis to the choroid is rare. Despite the combination of radiotherapy and chemotherapy, our patient's state of health deteriorated rapidly.

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睾丸绒毛膜癌伴脉络膜转移
睾丸肿瘤占男性恶性肿瘤的近1%,年龄在20至35岁之间的患者占6%。绒毛膜癌是一种源自未分化滋养细胞的高度转移性恶性肿瘤。睾丸肿瘤累及眼部极为罕见,发生率仅为0.2%。材料与方法一名23岁男子的疾病症状开始于伴有左眼视力障碍和眩晕的剧烈头痛。他被转介到泌尿科,因为一个增大的左睾丸与硬化的一致性。据报道,睾丸绒毛膜癌转移到脉络膜,肺和中枢神经系统。经过一个周期的化疗后,患者的生命功能迅速恶化,死于重症监护病房。病理报告为转移性睾丸绒毛膜癌。全世界共报告了18例,其中大多数预后很差。这些病例的预后很差,直到1970年引入以顺铂为基础的化疗。绒毛膜癌是睾丸癌的一种侵袭性变异,具有很高的转移潜力。尽管它的血液传播,它很少转移到脉络膜。结论睾丸癌是一种血液传播迅速的侵袭性睾丸癌。转移到脉络膜是罕见的。尽管放疗和化疗相结合,我们的病人的健康状况迅速恶化。
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来源期刊
Revista mexicana de urologia
Revista mexicana de urologia Medicine-Urology
CiteScore
0.20
自引率
0.00%
发文量
49
期刊介绍: Revista Mexicana de Urología (RMU) [Mexican Journal of Urology] (ISSN: 0185-4542 / ISSN electronic: 2007-4085) is bimonthly publication that disseminates research by academicians and professionals of the international medical community interested in urological subjects, in the format of original articles, clinical cases, review articles brief communications and letters to the editor. Owing to its nature, it is publication with international scope that disseminates contributions in Spanish and English that are rigorously reviewed by peers under the double blind modality. Neither journalistic documents nor those that lack rigorous medical or scientific support are suitable for publication.
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