Comparison of Genetic Variations in Zika Virus Isolated From Different Geographic Regions

Jooyeon Park, Jinhwa Jang, Insung Ahn
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Abstract

The Zika virus (ZIKV) belongs to the genus Flavivirus, together with Dengue virus, yellow fever virus, and West Nile virus. The virus, which was first found in Africa in 1947, has spread across the world owing to a lack of effective drugs or vaccines. The complete genome sequence of ZIKV is now available; it includes three structural and seven non-structure genes arranged in the order of capsid, pre-membrane, envelope, NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5. Two geographically distinct lineages are known, i.e., Asian and African, but ZIKV exhibits differences in clinical progression among regions.
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不同地理区域分离的寨卡病毒遗传变异的比较
寨卡病毒(ZIKV)与登革热病毒、黄热病病毒和西尼罗河病毒一起属于黄病毒属。这种病毒于1947年首次在非洲发现,由于缺乏有效的药物或疫苗,它已蔓延到世界各地。寨卡病毒的完整基因组序列现已获得;包括3个结构基因和7个非结构基因,排列顺序为衣壳、膜前、包膜、NS1、NS2A、NS2B、NS3、NS4A、NS4B、NS5。已知两个地理上截然不同的谱系,即亚洲和非洲,但寨卡病毒在不同地区的临床进展存在差异。
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