VACCINATION AGAINST A NEW CORONAVIRUS INFECTION IN PATIENTS WITH CANCER

M. Kostinov, V. Polishchuk, S. Mikhaylova, A. Dzhumagaziev, O. Usaeva
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Abstract

With a new coronavirus infection caused by SARS-CoV-2, cancer patients with malignant neoplasms are the most vulnerable group of people. Cancer patients are at a higher risk of severe COVID-19, and for them the vaccination of a new coronavirus infection is crucial. For cancer patients, the study of the effectiveness and safety of vaccination of a new coronavirus infection in large groups was not carried out. The available recommendations are based on data obtained on the safety and effectiveness of vaccines against SARS-CoV-2 in the general population, as well as on the study of the effectiveness and safety of other vaccines in cancer patients. It is believed that the potential benefits of vaccines against a new coronavirus infection outweigh the risks and therefore vaccination in these patients is recommended by cancer communities. All guidelines for the immunoprophylaxis of a new corona-virus infection in patients with oncopathology are temporary and will change as new data become available. It is necessary to personalize vaccination against COVID-19 in cancer patients. The problem of vaccination against SARS-CoV-2 in cancer patients requires in-depth study, conducting clinical tri-als from the standpoint of evidence-based medicine and evaluation on a sufficiently large number of patients.
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针对癌症患者的新型冠状病毒感染的疫苗接种
随着SARS-CoV-2引起的新型冠状病毒感染,恶性肿瘤的癌症患者是最脆弱的人群。癌症患者感染严重COVID-19的风险更高,对他们来说,接种新型冠状病毒感染疫苗至关重要。对于癌症患者,尚未开展大规模新型冠状病毒感染疫苗接种的有效性和安全性研究。现有的建议是基于针对SARS-CoV-2的疫苗在一般人群中的安全性和有效性所获得的数据,以及对其他疫苗在癌症患者中的有效性和安全性的研究。人们认为,针对新型冠状病毒感染接种疫苗的潜在益处大于风险,因此癌症社区建议为这些患者接种疫苗。所有针对肿瘤病理患者新型冠状病毒感染的免疫预防指南都是临时的,并将随着获得新数据而改变。有必要对癌症患者进行个性化的COVID-19疫苗接种。针对癌症患者接种SARS-CoV-2疫苗的问题,需要深入研究,从循证医学的角度进行临床试验,并对足够多的患者进行评估。
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