Attempts of chemical standardizing of Chrysanthemum parthenium as a prospective antimigraine drug.

D Gromek, W Kisiel, A Stojakowska, S Kohlmünzer
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Abstract

A quantitative analysis of biologically active sesquiterpene lactones in ethanol and aqueous extracts of Chrysanthemum parthenium and its form flosculosum was carried out. The sesquiterpene lactone contents in the extracts were comparable, although the contents of ethanol extracts (ca. 0.5%) were higher than of aqueous ones (ca. 0.3%). Parthenolide was found to be the main constituent of the lactones. The applied IR and TLC/FID methods for quantitative determination of the total sesquiterpene lactones and parthenolide, respectively, may be used for chemical standardizing of the raw material and its preparations.

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菊花parthenium作为抗偏头痛药物的化学标准化尝试。
对菊花及其形态花菊乙醇提取物和水提取物中具有生物活性的倍半萜内酯进行了定量分析。两种提取物的倍半萜内酯含量具有可比性,但乙醇提取物(约0.5%)的含量高于水提取物(约0.3%)。内酯的主要成分为孤香内酯。应用IR和TLC/FID方法分别定量测定总倍半萜内酯和对苯二酚内酯,可用于原料及其制剂的化学标准化。
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