[Clinico-electrophysiological study of vincristine neuropathy. Study of 6 leukemic children].

Abstract

A longitudinal clinical-electrophysiological study has been carried out on 6 leukaemic children during the treatment with vincristine. The Authors emphasize: 1) in the vincristine neuropathy the motor and sensitive fibres are initially affected in the distal segments with subsequent centripetal discussion, this agrees with the neuropathological picture characterized by distal axonal degeneration with processes dying-back type; 2) there is a relationship between dose-duration of the treatment and neurotoxic effects.