Endothelium-dependent effects of beta-adrenergic blockers.

Blood vessels Pub Date : 1990-01-01 DOI:10.1159/000158822
P M Vanhoutte
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引用次数: 5

Abstract

Nonselective beta-adrenergic blockers have been reported to affect endothelium-dependent responses in isolated blood vessels in the following ways: (a) cause endothelium-augmented direct relaxations; (b) facilitate the endothelium-dependent relaxations evoked by alpha 2-adrenergic activation, or by acetylcholine; (c) augment the intraluminal release of vasodilator prostanoids, and (d) inhibit endothelium-dependent contractions to anoxia. Important species differences exist in terms of the endothelium-dependent effects of the compounds. If they were to occur in the intact organism, the endothelium-dependent effects of the beta-adrenergic blockers could help to explain their vasodilator properties.

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肾上腺素能阻滞剂的内皮依赖性作用。
据报道,非选择性β -肾上腺素能阻滞剂通过以下方式影响离体血管的内皮依赖性反应:(a)引起内皮增强的直接松弛;(b)促进由α 2-肾上腺素能激活或乙酰胆碱引起的内皮依赖性松弛;(c)增加血管扩张剂前列腺素的腔内释放,(d)抑制内皮依赖性的缺氧收缩。就这些化合物的内皮依赖作用而言,存在重要的物种差异。如果它们发生在完整的生物体中,β -肾上腺素能阻滞剂的内皮依赖性作用可以帮助解释它们的血管扩张特性。
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