S. Tarun, Khichi Garima, Saxena Ashutosh, Goyal Ramakant, Salem Nitasha
{"title":"Diabetic Nephropathy – Pathophysiology: An Overview","authors":"S. Tarun, Khichi Garima, Saxena Ashutosh, Goyal Ramakant, Salem Nitasha","doi":"10.17352/ACN.000035","DOIUrl":null,"url":null,"abstract":"Background: Diabetic nephropathy (DN) is one of the commonest etiologies for ESRD. Various studies suggest that diabetic nephropathy occurs due to the accumulation of advanced glycosylated end products (AGEs), the activation of isoforms of protein C kinase, etc. Correlation of renal arterial flow resistance, GFR, and progression towards ESRD in DN is not well narrated in literature. Therefore, the main object of the study was to assess renal arterial flow resistance in patients with DN and to compare it with patients having non-evident diabetic nephropathy.","PeriodicalId":127781,"journal":{"name":"Archives of Clinical Nephrology","volume":"69 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Clinical Nephrology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17352/ACN.000035","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Diabetic nephropathy (DN) is one of the commonest etiologies for ESRD. Various studies suggest that diabetic nephropathy occurs due to the accumulation of advanced glycosylated end products (AGEs), the activation of isoforms of protein C kinase, etc. Correlation of renal arterial flow resistance, GFR, and progression towards ESRD in DN is not well narrated in literature. Therefore, the main object of the study was to assess renal arterial flow resistance in patients with DN and to compare it with patients having non-evident diabetic nephropathy.
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