M Devoto, L De Benedetti, P Ronchetto, L Romano, G Romeo, L C Tsui, M Dean, F Collins, M Seia, L Piceni Sereni
{"title":"New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.","authors":"M Devoto, L De Benedetti, P Ronchetto, L Romano, G Romeo, L C Tsui, M Dean, F Collins, M Seia, L Piceni Sereni","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"102-4"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Universitatis Carolinae. Medica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.
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